Supernumerary Centrosomes Nucleate Extra Cilia and Compromise Primary Cilium Signaling
نویسندگان
چکیده
منابع مشابه
Supernumerary Centrosomes Nucleate Extra Cilia and Compromise Primary Cilium Signaling
The primary cilium is a nexus of cell signaling, and ciliary dysfunction is associated with polycystic kidney disease, retinal degeneration, polydactyly, neural tube defects, and obesity (ciliopathies). Signaling molecules for cilium-associated pathways are concentrated in the cilium, and this is essential for efficient signaling. Cilia are nucleated from centrioles, and aberrant centriole numb...
متن کاملSignaling through the Primary Cilium
The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in...
متن کاملPrimary Cilium-Dependent Signaling Mechanisms
Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell. The overall function of a cilium is therefore to act as a communica...
متن کاملPrimary Cilium Patched 1 Regulates Hedgehog Signaling
www.sciencemag.org (this information is current as of July 23, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/317/5836/372 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/317/5836/372/DC1 can be found a...
متن کاملCildb: a knowledgebase for centrosomes and cilia
Ciliopathies, pleiotropic diseases provoked by defects in the structure or function of cilia or flagella, reflect the multiple roles of cilia during development, in stem cells, in somatic organs and germ cells. High throughput studies have revealed several hundred proteins that are involved in the composition, function or biogenesis of cilia. The corresponding genes are potential candidates for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2012
ISSN: 0960-9822
DOI: 10.1016/j.cub.2012.06.057